{"created":"2023-06-19T06:32:38.190509+00:00","id":26,"links":{},"metadata":{"_buckets":{"deposit":"7d72df4d-d584-46fb-ace8-490ab548df9d"},"_deposit":{"created_by":5,"id":"26","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"26"},"status":"published"},"_oai":{"id":"oai:nupals.repo.nii.ac.jp:00000026","sets":[]},"author_link":["22"],"item_10010_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Studies on effects of nuclear factor κB (NF-κB)-inhibiting natural compounds on drug efflux transporter P-glycoprotein"}]},"item_10010_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗がん剤使用におけるがん細胞の薬剤耐性化は広く知られており、P-糖タンパク質がATPの加水分解エネルギーを利用して薬物を輸送することが原因の1つとされている。\n また、転写因子Nuclear Factor-κB（NF-κB）は抗アポトーシス遺伝子の発現上昇を介して抗がん剤やdeath receptorを介するアポトーシス抑制に関与している。近年、さまざまな天然物がNF-κB阻害作用を介して抗腫瘍活性を持つことが明らかになり、分子レベルでの研究が行なわれている。NF-κBの阻害作用と抗腫瘍活性を合わせ持つ天然物の中でP-糖タンパク質による排泄機構を阻害することができる化合物を発見できれば、臨床において非常に有用なものとなると思われる。 \nそこで、本研究ではNF-κB 阻害作用が報告されている天然物を用いて、P-糖タンパク質のATPの加水分解に対する影響とNF-κBの活性化抑制の効果について検討した。その結果、Celastrol、Licochalcone A、Anacardic acid、Caffeic acid phenethyl ester (CAPE)、Xanthohumol、Magnolol、ＨonokiolはP-糖タンパク質の基質であると考えられ、P-糖タンパク質の排出能を上回る量の多量のNF-κB阻害天然物を添加、あるいはP-糖タンパク質の阻害作用を持つことが知られているVerapamilと併用することでNF-κBの活性化が阻害された。これらのことより、いくつかの天然物が、がんによる多剤耐性を克服し、がんの治療効果を向上させることが期待できる物質として有用なものとなることが示唆された。","subitem_description_type":"Abstract"}]},"item_10010_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"URI:  http://hdl.handle.net/10801/298 "}]}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大串, 祐一"}],"nameIdentifiers":[{"nameIdentifier":"22","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-24"}],"displaytype":"detail","filename":"06P020_大串  祐一.pdf","filesize":[{"value":"612.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"06P020_大串  祐一","url":"https://nupals.repo.nii.ac.jp/record/26/files/06P020_大串  祐一.pdf"},"version_id":"e0e53309-a7cf-4ff6-9e07-acdce47440e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"P-糖タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"ABCB1","subitem_subject_scheme":"Other"},{"subitem_subject":"KB/MDR1","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-κB","subitem_subject_scheme":"Other"},{"subitem_subject":"ABCトランスポーター","subitem_subject_scheme":"Other"},{"subitem_subject":"ルシフェラーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-κB阻害天然物","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"がん","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"抗腫瘍活性","subitem_subject_scheme":"Other"},{"subitem_subject":"Celastrol","subitem_subject_scheme":"Other"},{"subitem_subject":"Licochalcone A","subitem_subject_scheme":"Other"},{"subitem_subject":"Anacardic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"CAPE","subitem_subject_scheme":"Other"},{"subitem_subject":"Xanthohumol","subitem_subject_scheme":"Other"},{"subitem_subject":"Magnolol","subitem_subject_scheme":"Other"},{"subitem_subject":"Honokiol","subitem_subject_scheme":"Other"},{"subitem_subject":"Verapamil","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"薬物排出トランスポーター Ｐ-糖タンパク質に及ぼす転写因子ＮＦ-κＢ阻害天然物の影響に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬物排出トランスポーター Ｐ-糖タンパク質に及ぼす転写因子ＮＦ-κＢ阻害天然物の影響に関する研究"}]},"item_type_id":"10010","owner":"5","path":["6"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-02-02"},"publish_date":"2012-02-02","publish_status":"0","recid":"26","relation_version_is_last":true,"title":["薬物排出トランスポーター Ｐ-糖タンパク質に及ぼす転写因子ＮＦ-κＢ阻害天然物の影響に関する研究"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T06:50:28.867328+00:00"}