{"created":"2023-06-19T06:32:41.808627+00:00","id":100,"links":{},"metadata":{"_buckets":{"deposit":"2883c745-948b-499e-88c7-979c3ec47d57"},"_deposit":{"created_by":5,"id":"100","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"100"},"status":"published"},"_oai":{"id":"oai:nupals.repo.nii.ac.jp:00000100","sets":[]},"author_link":["95"],"item_10010_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Chemical Differences of Benzene Ring and Thiophene Ring Which Shows The Bioisostere"}]},"item_10010_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"医薬品の中には，含有される成分の構造でベンゼン環の部分構造がチオフェン環に置き 換わったものがある．一般にベンゼン環とチオフェン環は生物学的同等性を示すと言われている．そこで，ベンゼン環とチオフェン環を，ドラッグデザイン時に知り得ていた環の形状 からだけでなく，化学的な面や生体内の受容体との相互作用の面から見て，類似点，相違点を明確にすることにより，医薬品の薬理作用にどのような違いが出てくるのかをまとめた．その結果，生体内の受容体との相互作用の強さが環の形状を反映することが分かった．疎水性の相互作用の強さはπ−πスタッキングの起こりやすさにより決まり，ケトプロフェンとチアプロフェン酸を比較すると，ケトプロフェンの方が相互作用が強いために，早く代謝されることが分かった．","subitem_description_type":"Abstract"}]},"item_10010_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"URI:  http://hdl.handle.net/10801/465 "}]}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和田, 志織"}],"nameIdentifiers":[{"nameIdentifier":"95","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-31"}],"displaytype":"detail","filename":"07P270_和田　詩織.pdf","filesize":[{"value":"250.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"07P270_和田　詩織","url":"https://nupals.repo.nii.ac.jp/record/100/files/07P270_和田　詩織.pdf"},"version_id":"56d11a66-cfe5-464c-9369-37f813ba1648"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ベンゼン環","subitem_subject_scheme":"Other"},{"subitem_subject":"チオフェン環","subitem_subject_scheme":"Other"},{"subitem_subject":"生物学的同等性","subitem_subject_scheme":"Other"},{"subitem_subject":"相違点","subitem_subject_scheme":"Other"},{"subitem_subject":"疎水性相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"π−πスタッキング","subitem_subject_scheme":"Other"},{"subitem_subject":"プロトン化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"生物学的同等性を示すベンゼン環とチオフェン環の化学的相違点","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生物学的同等性を示すベンゼン環とチオフェン環の化学的相違点"}]},"item_type_id":"10010","owner":"5","path":["8"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-03-13"},"publish_date":"2013-03-13","publish_status":"0","recid":"100","relation_version_is_last":true,"title":["生物学的同等性を示すベンゼン環とチオフェン環の化学的相違点"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T06:48:21.407170+00:00"}